Flunarizine dihydrochloride

Research use only, not for human use.

Flunarizine is a selective calcium entry blocker.

Flunarizine is a selective calcium entry blocker.(In Vitro):Flunarizine blocks sodium currents (INa) and calcium currents (ICa) with IC50 values of 0.94 μM and 1.77 μM in cultured rat cortical neurons, respectively.Flunarizine (10 and 30 μM; 24 h) shows cytotoxic effects to chromaffin cells.Flunarizine (1-30 μM) causes clear cytoprotection of chromaffin cell at concentrations of 3-10 μM.(In Vivo):Flunarizine (intraperitoneal injection; 30?mg/kg; once) protects mice from lipopolysaccharide- (LPS-) induced acute lung injury (ALI).

Cell Viability Assay Cell Line:Chromaffin cells Concentration:10 and 30 μM Incubation Time:24 hours Result:Showed a tendency to increase cell death at the concentration of 10 μM, and showed near 100% cell loss at the concentration of 30 μM.

Animal Model:Male BALB/c mice (6-8 weeks old) with acute lung injury induced by lipopolysaccharide Dosage:30?mg/kg Administration:Intraperitoneal injection; 30?mg/kg; once Result:Suppressed the LPS-induced cell influx, protein leakage, and inflammatory cytokines release.Inhibited the pulmonary inflammation.

Flunarizine hydrochloride | Flunarizine HCl | EINECS 250-216-6 | KW-3149 | R 14950

GPCR/G Protein

Calcium Channel

Calcium Channel

Neurological Disease

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30484-77-6

477.42

C26H28Cl2F2N2

>98% (HPLC)

Ethanol: 3 mg/mL (6.28 mM); DMSO: 5 mg/mL (10.47 mM)

FC1=CC=C(C(N2CCN(C/C=C/C3=CC=CC=C3)CC2)C4=CC=C(F)C=C4)C=C1.[H]Cl.[H]Cl

1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine dihydrochloride

(-20℃)

With Ice Pack

≥ 2 years